Neurotoxins like Botox, Dysport, Daxxify, and Xeomin help smooth wrinkles by relaxing facial muscles, but how long they last and when to retreat depends on multiple factors. The ideal timing for your next session depends on whether you prefer some movement, no movement, or wait until wrinkles return. It also depends on the efficacy and completeness of your first treatment. And some people get a bit of movement in the forehead first. Let’s break it down.
Understanding Neurotoxin Differences, return of movement based on research
- Botox (OnabotulinumtoxinA) – The most well-known, takes 3-7 days for results, lasts around 3-4 months.
- Dysport (AbobotulinumtoxinA) – Has a quicker onset (2-3 days) and diffuses more, making it great for larger areas like the forehead. Lasts 3-4 months.
- Xeomin (IncobotulinumtoxinA) – Free from added proteins, potentially reducing resistance. Lasts about 3-4 months.
- Daxxify (DaxxibotulinumtoxinA-lanm) – The newest option, formulated with a stabilizing peptide, can last up to5- 6 months.
Retreatment Timing: How Often Should You Get Injections?
- Some Movement Preference – Retreatment every 12-14 weeks. Some prefer a softer look where they can still raise their eyebrows or smirk slightly while reducing deep wrinkles.
- No Movement Preference – Retreatment every 3-4 months. This keeps the muscles consistently relaxed to prevent creasing.
- Wait Until Wrinkles Return – Retreatment every 4-6 months, depending on metabolism and product used. Daxxify users can sometimes wait even longer.
Factors That Speed Up Toxin Breakdown
Some people burn through neurotoxins faster than others, especially:
- Athletes and Runners – Increased metabolism and blood circulation clear the product faster. Some runners report needing touch-ups in 6-8 weeks instead of 3-4 months.
- Frequent Facial Movement – If you make expressive movements often, the product may not last as long.
- Stress and High Cortisol – Chronic stress may accelerate breakdown.
- Frequent Sun Exposure and Heat (e.g., sauna users) – Can affect duration by increasing metabolism.
Combining Neurotoxins with Other Skin Treatments
For best results, consider combining neurotoxins with other treatments:
- Microneedling + PRP – Stimulates collagen and improves fine lines while Botox prevents deepening of expression lines.
- Chemical Peels or Laser Resurfacing – Improves skin texture and tone while Botox smooths wrinkles.
- Filler + Neurotoxin – Fillers restore volume while neurotoxins soften dynamic wrinkles, preventing a “heavy” look.
- Medical-Grade Skincare – Retinol, vitamin C, and peptides extend the results of injections by maintaining skin elasticity.
Neurotoxin Use During Weight Loss
If you are actively losing weight, keep in mind:
- Facial volume loss can reveal new wrinkles. Neurotoxins won’t restore volume, so pairing with fillers might be necessary.
- Faster metabolism from increased exercise may shorten the duration of results. Adjust your treatment schedule accordingly.
- Sagging skin from weight loss might benefit from skin-tightening treatments like RF microneedling or Ultherapy alongside neurotoxin use.
Final Thoughts
Choosing the right neurotoxin and treatment schedule depends on your aesthetic goals, lifestyle, and metabolism. If you prefer no movement, keep up with treatments every 3-4 months. If you like some movement, schedule every 8-12 weeks. Athletes and those with fast metabolisms may need more frequent treatments, while Daxxify users can sometimes go 6 months between sessions. For optimal skin health, consider pairing neurotoxins with complementary treatments to maintain a youthful, refreshed look.
